GHSR MODULATION BY LEAP2 IN PERINATAL PHASES IMPACTS GLUCOSE OVERLOAD RESPONSIVENESS IN YOUNG RATS
نویسندگان
چکیده
GHSr signaling is involved in the regulation of energy homeostasis. LEAP2, a recentlydiscovered peptide hormone, counteracts effects ghrelin. This study sought to evaluatethe perinatal LEAP2 exposure young rat offspring. For this, two protocols weredesigned assess roles antagonism during pregnancy and thelactation. Sex-specific impacts on AUC peak-responses glucose tolerance tests werepresented. However, no differences were detected blood mixed meal fedanimals. In conclusion, could impact glucose-stimulatedinsulin secretion rats.
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ژورنال
عنوان ژورنال: Arquivos do Mudi
سال: 2023
ISSN: ['1980-959X']
DOI: https://doi.org/10.4025/arqmudi.v27iespecial.68227